GRIA4 (Center) Rabbit Polyclonal Antibody

CAT#: AP51951PU-N

GRIA4 (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Glutamate receptor 4 / GLUR4 Antibody (Center) in K562 cell line lysates (35ug/lane). This demonstrates the GRIA4 antibody detected the GRIA4 protein (arrow).

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  Western blot analysis of Glutamate receptor 4 / GLUR4 Antibody (Center) in mouse spleen tissue lysates (35ug/lane). This demonstrates the GRIA4 antibody detected the GRIA4 protein (arrow).

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  Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with Glutamate receptor 4 / GLUR4 Antibody (Center) followed by peroxidase conjugation of the secondary antibody and DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 295-325 amino acids from the Central region of Human Glutamate receptor 4 / GLUR4.
• Specificity: This antibody recognizes Human and Mouse Glutamate receptor 4 / GLUR4 (Center).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: glutamate ionotropic receptor AMPA type subunit 4
• Database Link:
  Entrez Gene 14802 MouseEntrez Gene 2893 Human
  UniProt ID P48058
• Background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq].
• Synonyms: GluR-4, GRIA4, GluR-D, GluA4, Glutamate receptor ionotropic AMPA4
• Note: Molecular Weight: 100871 Da

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction