Calpain 6 (CAPN6) (Center) Rabbit Polyclonal Antibody

CAT#: AP50726PU-N

Calpain 6 (CAPN6) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

CAPN6 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CAPN6 antibody detected the CAPN6 protein (arrow).

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  CAPN6 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CAPN6 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western blot: 1/100 - 1/500.
  Immunohistochemistry on paraffin sections: 1/10 - 1/50.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 289-319 amino acids from the Central region of human CAPN6
• Specificity: This antibody reacts to CAPN6.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 74576 Da
• Gene Name: calpain 6
• Database Link:
  Entrez Gene 827 Human
  UniProt ID Q9Y6Q1
• Background: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.
• Synonyms: Calpamodulin, CAPN6, CALPM, CANPX

Reference Data

• Protein Families: Druggable Genome, Protease