IL12A Goat Polyclonal Antibody

CAT#: AP31605PU-N

IL12A goat polyclonal antibody, Aff - Purified

Product Images

Human Intestine, Paneth Cells: Formalin-Fixed, Paraffin-Embedded (FFPE).

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: ELISA: 1/16000.
  Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
• Reactivities: Canine, Human, Porcine, Monkey
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from human IL12A / p35
• Specificity: Recognizes Interleukin-12 alpha / IL12A.
• Formulation: Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Gene Name: interleukin 12A
• Database Link:
  Entrez Gene 3592 Human
  UniProt ID P29459
• Background: Interleukin 12 (IL12) can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine activated killer cells, and stimulate the production of IFN gamma by resting PBMC. IL12 induces IFN gamma, TNF alpha production in T and NK cells; costimulation of PBL proliferation; proliferation/differentiation of TH1 T lymphocytes. It is downregulated by IL10; homodimeric p40 antagonistic to functional p70 heterodimer. IL12R beta 1 binds p40 but when dimeric with IL12R beta 2 binds p35.
• Synonyms: IL-12A, IL-12 subunit p35, NKSF1, CLMF p35

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Allograft rejection, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus