B7-1 (CD80) Goat Polyclonal Antibody
Other products for "CD80"
Specifications
Product Data | |
Applications | ELISA, WB |
Recommended Dilution | Peptide ELISA: Detection Limit: 1/4000. Western blot: 0.3-1 µg/ml. Detects a band of Approx 60kDa band observed in Human Lymph Node and Human Tonsil lysates (calculated MW of 33.0kDa according to NP_005182.1). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. |
Reactivities | Human |
Host | Goat |
Clonality | Polyclonal |
Immunogen | Peptide with sequence from the internal region of the protein sequence according to NP_005182.1. |
Specificity | Recognizes CD80. |
Formulation | Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer. State: Aff - Purified State: Liquid purified IgG fraction. |
Concentration | lot specific |
Purification | Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide. |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | CD80 molecule |
Database Link | |
Background | CD80 is a member of the Ig superfamily and serves as the ligand for two T cell molecules, CD28 and CTLA4. Interactions between CD28 and CD80 on activated B cells result in enhanced T cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, Epstein Barr Virus (EBV) transformed B cell lines, Burkitts lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. It is also expressed at high levels in dendritic cells. It reacts weakly with a small proportion of non activated normal B cells and with HTLV1 infected T cells. CD80 does not react with peripheral monocytes, resting and activated normal T cells, T cell lines and T cell clones, nor with myelomonocytic cell lines. Cell Distribution: CD80 is rapidly induced on the surface of activated B cells, T cells and monocytes and is also expressed at high levels on dendritic cells. |
Synonyms | CD28LG, CD28LG1, LAB7, BB1, B7.1, B7-1 |
Reference Data |
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