CARD11 (18-238) Rabbit Polyclonal Antibody

CAT#: AP23584PU-N

CARD11 (18-238) rabbit polyclonal antibody, Aff - Purified

Product Images

Sample (30 ug of whole cell lysate). A: A431. B: Raji. 5% SDS PAGE. CARD11 antibody diluted at 1/1000.

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  Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500 - 1/3000.
• Reactivities: Bovine, Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 18 and 238 of Human CARD11
• Specificity: This antibody reacts to Caspase Recruitment Domain Family, Member 11 (CARD11).
• Formulation: 0.1 M Tris-glycine, pH 7.0 containing 10% Glycerol as stabilizer and 0.01% Thimerosal as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: caspase recruitment domain family member 11
• Database Link:
  Entrez Gene 108723 MouseEntrez Gene 84433 Human
  UniProt ID Q9BXL7
• Background: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the IkK complex, thereby regulating activation of the NF-kB transcription factor. Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.
• Synonyms: BIMP3; CARMA1; MGC133069

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: B cell receptor signaling pathway, T cell receptor signaling pathway