IL16 Rabbit Polyclonal Antibody

CAT#: AP20783PU-N

IL16 rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry (IHC) analyzes of IL-16 antibody (Cat.-No. AP20783PU-N) in paraffin-embedded human tonsil tissue.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of IL-16 protein.
  (region surrounding Gly97)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: interleukin 16
• Database Link:
  Entrez Gene 3603 Human
  UniProt ID Q14005
• Background: Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, intiate signal transduction cascades that elicit physiological changes in their target cells. Interleukin-16, or IL-16, is a cytokine that has chemoattractant activity on CD4+ T lymphocytes. It has long been known that eosinophils and CD4+ T lymphocytes are recruited to sites of allergic inflammation, but the molecular mechanism was poorly understood. IL-16, also referred to as lymphocyte chemoattractant factor, is secreted by activated eosinophils as part of the allergic response along with RANTES, an additional cytokine. Once bound to its cognate receptor, CD4, IL-16 initiates a signal cascade that results in the activation of the PKC family.
• Synonyms: IL-16, LCF

Reference Data

• Protein Families: Druggable Genome, Secreted Protein