CCNO Rabbit Polyclonal Antibody

CAT#: AP20519PU-N

CCNO rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of UDG antibody (Cat.-No.: AP20519PU-N) in extracts from HepG2 cells.

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  Immunohistochemistry (IHC) analyzes of UDG antibody (Cat.-No.: AP20519PU-N) in paraffin-embedded human skeletal muscle tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of UDG protein.
  (region surrounding His221)
• Formulation: PBS with 0.02% Sodium Azide, 50% glycerol, pH7.2
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 35 kDa
• Gene Name: cyclin O
• Database Link:
  Entrez Gene 218630 MouseEntrez Gene 499528 RatEntrez Gene 10309 Human
  UniProt ID P22674
• Background: The human UNG-gene encodes nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase using differentially regulated promoters, PA and PB, and alternative splicing to produce two proteins with unique N-terminal sorting sequences. Uracil in DNA may result from deamination of cytosine which can give rise to transition mutations. Uracil-DNA glycosylase is the DNA repair enzyme responsible for the removal of uracil from DNA. This is probably a biologically important function in the prevention of mutagenesis resulting from cytosine deamination. UNG2 removes misincorporated dUMP residues.
• Synonyms: UDG2, UNG2, CCNO