Cathepsin K (CTSK) Rabbit Polyclonal Antibody

CAT#: AP17260PU-N

Cathepsin K (CTSK) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of CTSK antibody (Center R222) in A375 cell line lysates (35 ug/lane). CTSK (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: FC, IHC, WB
• Recommended Dilution: Western blot: 1:1000.
  Immunohistochemistry on formalin-fixed, paraffin-embedded sections: 1:10 - 1:50.
  Flow Cytometry: 1:10 - 1:50.
• Reactivities: Bovine, Human, Monkey, Porcine, Rabbit
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between aa 207-27 from the Center region of human CTSK.
• Specificity: This antibody detects Cathepsin K at Center.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Purified through Protein A column followed by peptide affinity purification.
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: cathepsin K
• Database Link:
  Entrez Gene 1513 Human
  UniProt ID P43235
• Background: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing.
• Synonyms: Cathepsin O, Cathepsin X, Cathepsin O2, CTSK, CTSO, CTSO2
• Note: Molecular weight: 36966 Da

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Lysosome