Aromatase (CYP19A1) (Center) Rabbit Polyclonal Antibody

CAT#: AP14030PU-N

Aromatase (CYP19A1) (Center) rabbit polyclonal antibody, Purified

Product Images

CYP19A1 antibody staining of HL60 cell line lysates by Western blot (35 ug/lane). CYP19A1 (arrow) was detected using the purified antibody at 1/60 dilution.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Peptide ELISA: 1/1,000.
  Western blotting: 1/1000.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 221~253 amino acids from from the Central region of Human CYP19A1.
• Specificity: This antibody reacts to Aromatase (CYP19A1).
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: cytochrome P450 family 19 subfamily A member 1
• Database Link:
  Entrez Gene 1588 Human
  UniProt ID P11511
• Background: CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.
• Synonyms: Cytochrome P450 19A1, CYPXIX, Estrogen synthetase, P450AROM, CYP19A1, ARO1, CYAR, CYP19