SPHK1 (N-term) Rabbit Polyclonal Antibody
Other products for "SPHK1"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | ELISA: 1/1,000. Western blot: 1/100-1/500. |
Reactivities | Human |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of Human SPHK1. |
Specificity | This antibody detects SPHK1 at N-term. |
Formulation | PBS with 0.09% (W/V) Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Stability | Shelf life: one year from despatch. |
Gene Name | sphingosine kinase 1 |
Database Link | |
Background | Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720. |
Synonyms | SPHK, SPK, SPK 1, SPK-1 |
Note | Molecular weight: 42517 Da |
Reference Data |
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