BMPR1A (N-term) Rabbit Polyclonal Antibody

CAT#: AP11859PU-N

BMPR1A (N-term) rabbit polyclonal antibody, Purified

Product Images

The anti-BMPR1A is used in Western blot to detect BMPR1A in mouse muscle tissue lysate (Lane 1) and Hela cell lysate (Lane 2).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA 1:1,000.
  Western blotting 1:100 - 1:500.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human BMPR1A.
• Specificity: This antibody detects BMPR1A at N-term.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
• Conjugation: Unconjugated
• Storage: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: bone morphogenetic protein receptor type 1A
• Database Link:
  Entrez Gene 657 Human
  UniProt ID P36894
• Background: The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPRIA binds BMP4 with high-affinity in solution and is a potent BMP-4 antagonist in vitro. In adult tissues, BMPRIA is widely expressed, with the highest expression levels detected in skeletal muscle. BMPRIA is also widely expressed during embryogenesis.
• Synonyms: ACVRLK3, ALK3, ALK-3, SKR5
• Note: Molecular weight: 60198 Da