BAX (BH3 Domain) Rabbit Polyclonal Antibody
Other products for "BAX"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100. |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | This antibody was developed against a synthetic peptide selected from the N-terminal region (BH3 domain) of human Bax. |
Specificity | This antibody is specific to Bax (BH3 Domain). |
Formulation | PBS containing 0.09% (W/V) Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction. |
Concentration | lot specific |
Purification | Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | BCL2 associated X protein |
Database Link | |
Background | Bax belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bax forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of the Bax gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. |
Synonyms | Apoptosis regulator BAX, BCL2L4, Bcl2-L-4 |
Note | Calculated MW: 24220 Da |
Reference Data |
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