IL1 Receptor II (IL1R2) Rabbit Polyclonal Antibody

CAT#: AP07592PU-N

IL1 Receptor II (IL1R2) rabbit polyclonal antibody, Purified

Product Images

AP07592PU-N CD121b/IL1R2 antibody staining of Formalin-Fixed Paraffin-Embedded Human Small intestine, Peyer's patch at 10 ug/ml followed by biotinylated goat anti-Rabbit IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen.

Specifications

Product Data

• Applications: ELISA, IF, IHC, IP, WB
• Recommended Dilution: ELISA.
  Immunofluorescence.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Immunoprecipitation.
  Western Blot.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant Human IL-1R type II.
• Specificity: Recognizes CD121b / IL1R2.
• Formulation: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide as preserevative.
  State: Purified
  State: Liquid purified IgG fraction.
• Concentration: lot specific
• Purification: Protein A Chromatography.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: interleukin 1 receptor type 2
• Database Link:
  Entrez Gene 7850 Human
  UniProt ID P27930
• Background: CDw121b is a 65 kD member of the immunoglobulin superfamily also known as IL-1 receptor (IL-1R) type II. The IL-1R family is composed of three proteins: IL-1R type I, IL-1R type II, and the widely expressed IL-1R AcP. Both IL-1R type I and type II bind IL-1 alpha and IL-1 beta, although with differing affinities. The high affinity complex consists of IL-1R type I and IL-1R AcP, whereas IL-1 binds to IL-1R type II with low affinity. The IL-1 receptor antagonist (IL-1RA) can bind to both IL-1R type I and II. IL-1R type II is expressed at low levels on B cells, monocytes/macrophages, neutrophils, basal epithelia of the skin, and T cells. Binding of IL-1 to the high affinity IL-1 receptor mediates thymocyte and T cell activation, fibroblast proliferation, and induction of acute phase protein production. Binding of IL-1 to CDw121b appears to be dispensable for IL-1 signaling and may negatively regulate IL-1 responses acting as a quotdecoy quot receptor.
• Synonyms: Interleukin-1 receptor type II, IL-1R-2, IL-1R-beta, CDw121b, IL1RB