Tyrosine Hydroxylase (TH) Rabbit Polyclonal Antibody
CAT#: AP06357PU-N
Tyrosine Hydroxylase (TH) rabbit polyclonal antibody, Aff - Purified
Other products for "TH"
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | Western blot: 1/500-1/1000. Immunoflourescence: 1/50-1/200. Immunohistochemistry Paraffin Sections: 1/50-1/200. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to the N-terminus of Human TH. |
Specificity | This antibody detects endogenous levels of Tyrosine Hydroxylase protein. (region surrounding Gly13) |
Formulation | PBS, pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 0.05% sodium azide |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography using epitope-specific immunogen |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: One year from despatch. |
Predicted Protein Size | ~ 58 kDa |
Gene Name | tyrosine hydroxylase |
Database Link | |
Background | The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson’s disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds. |
Synonyms | Tyrosine 3-hydroxylase, TYH |
Reference Data |
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