CX3CR1 (175-189) Rabbit Polyclonal Antibody

CAT#: AP05819PU-N

CX3CR1 (175-189) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of CX3CR1 in THP-1 cell lysate in the absence (lane A) or presence (lane B) of blocking peptide with

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  Immunocytochemical staining of Human spleen with Rabbit anti human CX3CR1

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western blot: 1:500.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide corresponding to amino acids 175 to 189 of human CX3CR1.
• Specificity: This antibody recognises CX3CR1, a seven transmembrane protein recently identified as a receptor for fractalkine. CX3CR1 is expressed in a variety of human tissues and mediates leucocyte adhesion and migration.
• Formulation: Phosphate buffered saline containing 0.02% Sodium Azide
  State: Purified
  State: Liquid purified IgG
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: C-X3-C motif chemokine receptor 1
• Database Link:
  Entrez Gene 1524 Human
  UniProt ID P49238
• Background: CX3CR1 is one of the chemokine receptors that are required as co-receptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration and adhesion and has been implicated in tumor metastasis. CX3CR1 is expressed in a variety of human tissues and cell lines.
• Synonyms: CX3C chemokine receptor 1, C-X3-C CKR-1,CMKBRL1, CMK-BRL-1

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction