RNF34 Rabbit Polyclonal Antibody

CAT#: AP05687PU-N

RNF34 rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: ELISA: 1800 - 1:4000.
  Western Blot: 1:100 - 1:600; detects a band of approximately 42kDa.
• Reactivities: Bovine, Canine, Human, Mouse, Primate, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein corresponding to amino acids 1-373 of human RFI.
• Specificity: This antibody detects Ring Finger homologous to Inhibitor of apoptosis protein (hRFI).
• Formulation: Phosphate buffered saline pH7.2 containing 0.01% Sodium Azide (NaN3)
  State: Purified
  State: Liquid purified IgG
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: ring finger protein 34
• Database Link:
  Entrez Gene 80751 MouseEntrez Gene 282845 RatEntrez Gene 80196 Human
  UniProt ID Q969K3
• Background: RFI is an anti-apoptotic protein which has been shown to be a novel modulator of NF-kB activation, leading to the upregulation of Bcl2 and BclXL. It is also thought to possess E3 ubiquitin protein ligase activity and has been shown to target caspases 8 and 10 for proteasomal degradation. hRFI is expressed ubiquitously, and has been localized to both the nucleus and the cytoplasm. hRFI is also expressed in oesophageal, gastric and colorectal cancers, suggesting a possible association between hRFI and the development of digestive tract cancers.
• Synonyms: CARP1, CARP-1, RIFF

Reference Data

• Protein Families: Druggable Genome