PDGF Receptor beta (PDGFRB) Rabbit Polyclonal Antibody

CAT#: AP02728PU-N

PDGF Receptor beta (PDGFRB) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extract from 293 cells, using PDGF Receptor β antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1:500~1:1000.
• Reactivities: Human, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human PDGF Receptor β around the phosphorylation site of tyrosine 751(V-D-YP-V-P).
• Specificity: PDGF Receptor β antibody detects endogenous levels of total PDGF Receptor β protein.
• Formulation: PBS (without Mg2+ and Ca2+), pH 7.4 containing 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  State: Aff - Purified
  State: Liquid purified IgG
• Concentration: lot specific
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Conjugation: Unconjugated
• Storage: Store the antibody at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: platelet derived growth factor receptor beta
• Database Link:
  Entrez Gene 5159 Human
  UniProt ID P09619
• Background: Platelet-derived growth factor receptors exhibit tyrosine-protein kinase activity and have been implicated in the control of cell proliferation, survival and migration. PDGF receptors, PDGFR-alpha and PDGFR-beta, have 5 extracellular immunoglobulin-like domains and an intracellular tyrosine kinase domain. Upon binding a PDGF, the receptors form homo-and heterodimers. Dimerization of the receptors results in phosphorylation in the complex. More than 10 different SH2-domain-containing molecules have been shown to bind to different autophosphorylation sites in the PDGF-alpha and beta receptors. PDGF alpha receptors are expressed in oligodendrocyte progenitor cells and PDGF beta receptors are expressed on neurons.
• Synonyms: PDGF-R-beta, PDGF Receptor beta