GSK3 beta (GSK3B) pTyr216 Rabbit Polyclonal Antibody
Other products for "GSK3B"
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | Western Blot: 1/500~1/1000. Incubate membrane with diluted antibody in 5% nonfat milk, 1xTBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight. Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Peptide sequence around phosphorylation site of tyrosine 279/216 (V-S-Y(p)-I-C) derived from Human GSK3α/β. |
Specificity | The antibody detects endogenous level of GSK3α/β only when phosphorylated at tyrosine 279/216. |
Formulation | PBS (without Mg2+ and Ca2+), pH 7.4 containing 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol. State: Aff - Purified State: Liquid purified IgG fraction. |
Concentration | lot specific |
Purification | Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | glycogen synthase kinase 3 beta |
Database Link | |
Background | Glycogen Synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. GSK3 has been implicated in fundamental cell processes such as cell fate determination, metabolism, transcriptional control and oncogenesis. Two isoforms, alpha (GSK3A; OMIM 606784) and beta (GSK3B) show a high degree of amino acid homology within their catalytic domains. GSK3B is involved in energy metabolism, neuronal cell development and body pattern formation. |
Synonyms | GSK-3 beta, Glycogen synthase kinase-3 beta, GSK3B |
Note | Molecular Weight: 46 kDa, 51 kDa |
Reference Data |
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