BCR pTyr177 Rabbit Polyclonal Antibody
Other products for "BCR"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | Western Blot: 1/500-1/1000. |
Reactivities | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | p-Bcr (pTyr177) antibody detects endogenous levels of p-Bcr protein. |
Formulation | Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction |
Concentration | 1.0 mg/ml |
Purification | Affinity chromatography |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | ~ 160 kDa |
Gene Name | BCR, RhoGEF and GTPase activating protein |
Database Link | |
Background | The Bcr gene, mapping on chromosome 22, was initially identified on the basis of its fusion with the c-Abl proto-oncogene on chromosome 9 resulting in the generation of the Philadelphia chromosome in 90-95% of patients with chronic myelogenous leukemia (CML). The Bcr gene encodes for the Breakpoint cluster region protein (Bcr). A consequence of this translocation is the generation of a Bcr/c-Abl mRNA encoding an activated c-Abl protein kinase. The Bcr gene has been shown to encode a 160 kDa GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, Rac 1 p21. While it has been speculated that the Bcr protein may also stimulate Rac 2 p21 GTPase activity, it has no effect on Ras p21 or Rho p21 GTPases. It is of interest that the GAP domain of Bcr maps outside of the region that remains on chromosome 22 (Philadelphia chromosome) in CML. |
Synonyms | Breakpoint cluster region protein, BCR1, D22S11, NY-REN-26 |
Reference Data |
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