GPR91 (SUCNR1) Rabbit Polyclonal Antibody
GPR91 (SUCNR1) rabbit polyclonal antibody, Aff - Purified
|Recommended Dilution||Western Blot: 1/500-1/1000.
|Reactivity||Human, Mouse, Rat|
|Immunogen||Synthetic peptide, corresponding to amino acids 102-154 of Human GPR91.|
|Specificity||This antibody detects endogenous levels of GPR91 protein surrounding Ala135.|
|Formulation||Phosphate buffered saline (PBS), pH~7.2
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Preservative: 0.05% Sodium Azide
|Purification||Affinity Chromatography using epitope-specific immunogen|
|Storage||Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Predicted Protein Size||~38 kDa|
|Gene Name||Homo sapiens succinate receptor 1 (SUCNR1)|
|Background||GPR91 (formerly known as P2U2) is a G protein-coupled, dicarboxylic acid succinate receptor. It has a high level of expression in the kidney, predominantly in the proximal tubules, and localizes to the plasma membrane. It has also been found at low levels in the liver and the spleen. GPR91 functions as a citric acid cycle intermediate succinate receptor. Two signaling pathways result from GPR91 activation, the pertussis-toxin-sensitive Gi/Go pathway and the pertussis-toxin-insensitive Gq pathway. Four amino acid residues are necessary for GPR91 activation by succinate: Arg 99, His 103, Arg 252 and Arg 281. GPR91 plays an important role in the succinate-induced hypertensive effect and may be involved in renovascular hypertension, a disease linked to diabetes, renal failure and atherosclerosis.|
|Synonyms||G-protein coupled receptor 91, P2Y purinoceptor 1-like|
|Protein Families||Druggable Genome, GPCR, Transmembrane|