VEGF Receptor 1 (FLT1) Mouse Monoclonal Antibody [Clone ID: FLT1/658]

CAT#: AM50321PU-T

VEGF Receptor 1 (FLT1) mouse monoclonal antibody, clone FLT1/658, Purified

Specifications

Product Data

• Clone Name: FLT1/658
• Recommended Dilution: ELISA: Use BSA Antibody for coating.
  Functional Studies: Use BSA and Azide free Antibody.
  Positive Control: 293FT or A431 cells. Cerebellum or skin cancer.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human VEGF-R1 protein.
• Specificity: Recognizes Human VEGF-R1 / FLT-1. Other species not tested.
  Cellular Localization: Cell surface.
• Formulation: 10mM PBS
  State: Purified
  State: Liquid purified IgG fraction from Bioreactor Concentrate
  Stabilizer: 0.05% BSA
  Preservative: 0.05% Sodium Azide
• Concentration: lot specific
• Purification: Protein A/G Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 150-180 kDa
• Gene Name: fms related tyrosine kinase 1
• Database Link:
  Entrez Gene 2321 Human
  UniProt ID P17948
• Background: Three cell membrane receptor tyrosine kinases, Flt-1 (also designated VEGF-R1), Flk-1 (also designated VEGF-R2) and Flt-4, putatively involved in the growth of endothelial cells, are characterized by the presence of seven immunoglobulin-like sequences in their extracellular domain. These receptors exhibit high degrees of sequence relatedness to each other as well as lesser degrees of relatedness to the class III receptors including CSF-1/Fms, PDGR, SLFR/Kit and Flt-3/Flk-2. Two members of this receptor class, Flt-1 and Flk-1, have been shown to represent high affinity receptors for vascular endothelial growth factors (VEGFs). On the basis of structural similarity to Flt-1 and Flk-1, it has been speculated that Flt-4 might represent a third receptor for either VEGF or a VEGF-related ligand.
• Synonyms: VEGFR1, FLT1, FLT, FRT, VEGF Receptor 1