Plasma Cell Mouse Monoclonal Antibody [Clone ID: LIV3G11]

CAT#: AM32826PU-S

Plasma Cell mouse monoclonal antibody, clone LIV3G11, Purified

Product Images

Formalin-paraffin human tonsil stained with Plasma Cell Marker MAb (Clone LIV3G11).

Specifications

Product Data

• Clone Name: LIV3G11
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: Use Plasma Cell antibody at 0.5-1 µg/ml for 30 minutes at RT.
  Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
  Positive Control: Tonsil or Lymph node.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Pancreatic cancer related serum Mucin.
• Specificity: LIV3G11 antibody recognizes an intracytoplasmic antigen which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells.
  This monoclonal antibody superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. Plasma Cell Marker antibody is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lymphoplasmacytoid lymphoma from lymphocytic and follicular lymphoma.
  Note that this MAb is not suitable for staining frozen tissues.
  Cellular Localization: Cytoplasmic.
  Negative Species: Rat.
• Formulation: 10mM PBS
  State: Purified
  State: Liquid purified IgG fraction from Bioreactor Concentrate
  Stabilizer: 0.05% BSA
  Preservative: 0.05% Sodium Azide
• Concentration: lot specific
• Purification: Protein A/G Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Background: Plasma cells (also called plasma B cells or plasmocytes), which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement.
• Synonyms: Plasma B cell, Plasmocytes
• Note: Clone LIV3G11 is the same as 7B18