CD71 (TFRC) Mouse Monoclonal Antibody [Clone ID: 3B8 2A1]

CAT#: AM32281PU-N

CD71 (TFRC) mouse monoclonal antibody, clone 3B8 2A1, Purified

Specifications

Product Data

• Clone Name: 3B8 2A1
• Applications: ELISA, IHC, IP, WB
• Recommended Dilution: ELISA.
  Flow Cytometry.
  Immunoassay.
  Western Blot.
  Immunoprecipitation.
  Immunohistochemistry on frozen sections.
  The typical starting working dilution is 1/10.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity: This antibody reacts to Transferrin Receptor 1.
• Formulation: PBS
  State: Purified
  State: Liquid purified Ig fraction
  Stabilizer: 0,1% BSA
  Preservative: 0.02% sodium azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C.

• Stability: Shelf life: one year from despatch.

• Gene Name: transferrin receptor
• Database Link:
  Entrez Gene 7037 Human
  UniProt ID P02786
• Background:

  Human transferrin receptor 1 (TfR1), also designated CD71, is a homodimeric type II membrane glycoprotein of 90-95 kDa. This receptor binds two molecules of the serum iron-transport protein transferrin (Tf) and is internalised into endosomes that are acidified, resulting in the release of iron from Tf. TfR1 is not expressed on resting leukocytes but is upregulated on all proliferating cells upon activation, reflecting the iron dependence of proliferation. In tissues TfR1 is expressed on most dividing cells and on brain capillary endothelium. Expression of TfR1 is down regulated as a result of iron overload. TfR1 shares 45% identity with TfR2.

• Synonyms: TfR1, p90, Transferrin receptor protein 1