Integrin beta 1 (ITGB1) Mouse Monoclonal Antibody [Clone ID: DF7]

CAT#: AM32088PU-N

Integrin beta 1 (ITGB1) mouse monoclonal antibody, clone DF7, Ig Fraction

Specifications

Product Data

• Clone Name: DF7
• Applications: ELISA, IHC, WB
• Recommended Dilution: Western blotting: 1/1000.
  Immunohistochemistry.
  Other Immunoassays for cellular and tumor biology.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Wheat germ agglutinin binding glycoproteins of Human fibroblasts.
  Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
• Specificity: The antibody reacts with the b1 subunit of the integrin protein family. It reacts with an extracellular epitope of the beta-1 integrin molecule.
• Formulation: PBS
  State: Ig Fraction
  State: Liquid Ig fraction
  Stabilizer: 1.0% BSA
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C.
  
• Stability: Shelf life: one year from despatch.
• Gene Name: integrin subunit beta 1
• Database Link:
  Entrez Gene 3688 Human
  UniProt ID P05556
• Background: CD29 or the integrin beta-1 belongs to the family of cell adhesion receptors. It was initially characterized independently as protein gpIIa appearing on platelets, as the common beta subunit of the very late activation antigen (VLA), and as a component of various protein complexes binding to extracellular matrix proteins. The CD29 is expressed at the cell surface exclusively as part of a heterodimer, in association with one of at least nine different integrin alpha subunits (alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, alpha 6, alpha 7, alpha 8, and alpha v). With the exception of red blood cells and possible weak expression on granulocytes, CD29 is expressed nearly all cell and tissue types.
  Monoclonal antibodies against this β1-Integrin subunit are applicable in paraffin-embedded and frozen sections, immunoblotting and immunoprecipitation. Numerous studies have shown that β1 -Integrins have a distinct and wide cellular distribution and that there are alterations in malignant cells in their beta-1 integrin expression.
• Synonyms: Fibronectin receptor subunit beta, Integrin VLA-4 subunit beta, ITGB1, FNRB, MDF2, MSK12