CEACAM1 Mouse Monoclonal Antibody [Clone ID: B-D60]

CAT#: AM31274FC-N

CEACAM1 mouse monoclonal antibody, clone B-D60, FITC

Product Images

A typical staining pattern with the B-D60 FITC monoclonal antibody of granulocytes

Specifications

Product Data

• Clone Name: B-D60
• Applications: FC
• Recommended Dilution: Flow Cytometry: Use 10 µl to label 10⁶ cells or 100 µl of whole blood.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Skin derived T cell clone
• Specificity: This antibody recognises CD66a, a 160 kDa protein.
• Formulation: PBS
  Label: FITC
  State: Liquid purified IgG fraction
  Stabilizer: 5% BSA
  Preservative: 0.09% Sodium Azide
  Label: Fluorescein isothiocyanat
• Purification: Ion Exchange Chromatography
• Conjugation: FITC
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: carcinoembryonic antigen related cell adhesion molecule 1
• Database Link:
  Entrez Gene 634 Human
  UniProt ID P13688
• Background: CEACAM1 (BGP/CD66a) is a transmembrane glycoprotein which belongs to the carcinoembryonic antigen (CEA) gene family. It is expressed on cells of epithelial and myeloid origin and mediates homophilic intercellular interactions that influence cellular growth, immune cell activation, and tissue morphogenesis. CEACAM1 is a putative tumour suppressor based on diminished expression in some aggressive types of cancer cells. The anti-tumour effect may be due to inhibition of tumour angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAM.
• Synonyms: BGP, BGP1, Biliary glycoprotein 1

Reference Data

• Protein Families: Druggable Genome, Transmembrane