DEP1 (PTPRJ) (1-444) Mouse Monoclonal Antibody [Clone ID: MEM-CD148/05]

CAT#: AM26703BT-N

DEP1 (PTPRJ) (1-444) mouse monoclonal antibody, clone MEM-CD148/05, Biotin

Specifications

Product Data

• Clone Name: MEM-CD148/05
• Applications: FC
• Recommended Dilution: Indirect Immunofluorescence analysis by Flow cytometry.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Human recombinant CD148 (amino acids 1-444)
• Formulation: Phosphate buffered saline (PBS)
  Label: Biotin
  State: Liquid purified Ig fraction
  Preservative: 15 mM sodium azide, approx. pH 7.4
  Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
• Concentration: lot specific
• Conjugation: Biotin
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  
• Stability: Shelf life: one year from despatch.
• Gene Name: protein tyrosine phosphatase, receptor type J
• Database Link:
  Entrez Gene 5795 Human
  UniProt ID Q12913
• Background: CD148 (also known as HPTP-eta or DEP-1) is a transmembrane protein tyrosin phosphatase containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leucocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.
• Synonyms: DEP1, DEP-1, HPTP eta, R-PTP-eta, Protein-tyrosine phosphatase eta, R-PTP-J