DC SIGN (CD209) Mouse Monoclonal Antibody [Clone ID: UW60.1]

CAT#: AM26379PU-N

DC SIGN (CD209) mouse monoclonal antibody, clone UW60.1, Aff - Purified

Specifications

Product Data

• Clone Name: UW60.1
• Applications: FC, IF
• Recommended Dilution:

  Flow Cytometry.
  Immunohistochemistry.
  Immunocytochemistry.

• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: CD209-His-tagged fusion protein
• Specificity: The mouse monoclonal antibody UW60.1 recognizes CD209 (DC-SIGN), a 44 kDa transmembrane receptor expressed on the surface of dendritic cells and macrophages.
• Formulation: PBS, approx. pH 7.4
  State: Aff - Purified
  State: Liquid Ig fraction
  Preservative: 15 mM sodium azide
• Concentration: lot specific
• Purification: Protein-A affinity chromatograpy ( > 95% by SDS-PAGE)
• Conjugation: Unconjugated
• Storage:

  Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: CD209 molecule
• Database Link:
  Entrez Gene 30835 Human
  UniProt ID Q9NNX6
• Background: CD209, also known as DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin) is a transmembrane receptor expressed on the surface of dendritic cells and macrophages, which recognizes numerous pathogens ranging from parasites to viruses. Its N-terminal domain is transmembrane, whereas a tandem-repeat neck domain and the C terminal C-type lectin carbohydrate recognition domain have dual function as a pathogen recognition receptor and a cell adhesion receptor. The neck region is responsible for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. A ligand of CD209 is also CD50 (ICAM-3).
• Synonyms: DCSIGN1, DCSIGN, DC-SIGN1, CLEC4L, Dendritic Cell Marker