MGO-modified proteins Mouse Monoclonal Antibody [Clone ID: MGO-1]

CAT#: AM26368PU-N

MGO-modified proteins mouse monoclonal antibody, clone MGO-1, Purified

Specifications

Product Data

• Clone Name: MGO-1
• Applications: ELISA, IHC, WB
• Recommended Dilution: Immunoassays.
  Immunohistochemistry on paraffin sections: The typical starting working dilution is 1:50.
  Western blot.
• Reactivities: var.
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: MGO-modified KLH
• Specificity: The monoclonal antibody MGO-1 recognizes human MGO modified proteins.
• Formulation: PBS
  State: Purified
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% bovine serum albumin
  Preservative: 0.02% sodium azide
• Concentration: lot specific
• Purification: Protein G
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C.
  
• Stability: Shelf life: one year from despatch.
• Background: Methylglyoxal (MGO) is an endogenous product of glucose metabolism. Increased production and accumulation of methylglyoxal (MGO), as well as increased modification of proteins by glycoxidation, are hallmarks of aging and diabetes. MGO was shown to modify proteins and to contribute to the accumulation of damaged proteins that can be toxic to cells. A number of studies have shown that MGO levels are significantly elevated in patients with Type 2 Diabetes and correlates well with fasting plasma glucose and hemoglobin A1c (HbA1c) levels. Moreover, increased formation of the MGO is implicated in renal dysfunction and is known to be involved in the development of DN (diabetic nephropathy).