p53(TP53) Mouse Monoclonal Antibody [Clone ID: IMD-53]
Mouse Monoclonal Anti-TP53 Antibody, Purified
Product Datasheet for 'AM20653PU-N'
|Recommend Dilution||ICC/IF, IHC, WB|
|Immunogen||Recombinant Human wild-type p53 protein.|
|Formulation||1.2% Sodium Acetate with 2 mg BSA and 0.01 mg Sodium Azide as preservative|
|Concentration||0.1 mg/ml (after reconstitution with PBS)|
|Predicted Protein Size||44.1KDa|
|Gene Name||tumor protein p53|
|Background||The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to sublethal or severe DNA damage, respectively, by differential transcription of target genes and through transcription-independent apoptotic functions. The p53 protein contains 393 amino acids. Human p53 tumour antigen is Locatedto band 17p13. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.|
|Protein Families||Stem cell - Pluripotency, Transcription Factors, Druggable Genome|
|Protein Pathways||MAPK signaling pathway, Cell cycle, p53 signaling pathway, Apoptosis, Wnt signaling pathway, Neurotrophin signaling pathway, Amyotrophic lateral sclerosis (ALS), Huntington's disease, Pathways in cancer, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Basal cell carcinoma, Melanoma, Bladder cancer, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.