Ctla4 Hamster Monoclonal Antibody [Clone ID: 1B8]

CAT#: AM08060PU-N

Ctla4 hamster monoclonal antibody, clone 1B8, Purified

Specifications

Product Data

• Clone Name: 1B8
• Applications: FC, FN, IP
• Recommended Dilution: Flow Cytometry. (Ref.1,2)
  Immunoprecipitation. (Ref.1)
  In vitro Functional Studies. (Ref.1,2)
  Enhancement of tumor immunity. (Ref.3)
• Reactivities: Mouse
• Host: Hamster
• Isotype: IgG
• Clonality: Monoclonal
• Specificity: This Monoclonal antibody is specific to CD152/CTLA-4.
• Formulation: 100 mM Borate Buffered Saline, pH 8.2.
  No preservatives or amine-containing buffer salts added.
  State: Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: cytotoxic T-lymphocyte-associated protein 4
• Database Link:
  Entrez Gene 12477 Mouse
  UniProt ID P09793
• Background: The lymphocyte surface antigen CD152, also known as CTLA-4, is related to the co-stimulatory molecule CD28, and both molecules share common B7 family counter-receptors. (Ref.1-4) However CD152 is thought to be a negative regulator of T cell activation (Ref.1-3) and may play a role in apoptotic control of T cells. CD152 exists as a 69 kDa homodimer (Ref.1), and is relatively conserved among Humans, Mice and Chickens. (Ref.2)
• Synonyms: CTLA-4