HEXA Mouse Monoclonal Antibody [Clone ID: 3F10]

CAT#: AM06756PU-N

HEXA mouse monoclonal antibody, clone 3F10, Purified

Product Images

Western blot analysis using HEXA antibody against human HEXA (AA: 29-181) recombinant protein (Expected MW is 43.1 kDa).

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  Western blot analysis using HEXA antibody against L1210 (1), and HL7702 (2) cell lysate.

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  Flow Cytometric analysis of HeLa cells using HEXA antibody (green) and negative control (red).

Specifications

Product Data

• Clone Name: 3F10
• Applications: ELISA, FC, WB
• Recommended Dilution: ELISA: 1/10000.
  Western Blot: 1/500 - 1/2000.
  Flow Cytometry: 1/200 - 1/400.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of Human HEXA expressed in E. Coli.
• Specificity: Recognizes Beta-hexosaminidase alpha / HEXA
• Formulation: PBS
  State: Purified
  State: Liquid purified antibody
  Stabilizer: 0.5% protein stabilizer
  Preservative: 0.05% Sodium Azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 60.7 kDa
• Gene Name: hexosaminidase subunit alpha
• Database Link:
  Entrez Gene 3073 Human
  UniProt ID P06865
• Background: This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).
• Synonyms: beta-N-acetylhexosaminidase; MGC99608; N-acetyl-beta-glucosaminidase; TSD