Eph receptor A2 (EPHA2) Mouse Monoclonal Antibody [Clone ID: 1B3C7]

CAT#: AM06122SU-N

Eph receptor A2 (EPHA2) mouse monoclonal antibody, clone 1B3C7, Ascites

Product Images

Western blot analysis using EphA2 antibody Cat.-No AM06122SU-N against NIH/3T3 cell lysate.

• 

  Immunohistochemical analysis of paraffin-embedded human skin carcinoma (left) and pancreas carcinoma (right) tissue, showing cytoplasmic localization using EphA2 antibody Cat.-No AM06122SU-N with DAB staining.

Specifications

Product Data

• Clone Name: 1B3C7
• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/10000.
  Western Blot: 1/500 - 1/2000.
  Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgM
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of EphA2 expressed in E. Coli.
• Specificity: Recognizes EPH receptor A2 (EphA2)
• Formulation: State: Ascites
  State: Ascitic fluid
  Preservative: 0.03% Sodium Azide
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: EPH receptor A2
• Database Link:
  Entrez Gene 1969 Human
  UniProt ID P29317
• Background: EPH receptor A2 (EphA2), with 976-amino acid protein (about 107 kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphA10, EphB1, EphB2, EphB3, EphB4 and EphB6 are Eph family receptors for Ephrin family ligands. In normal cells, EphA2 negatively regulates cell growth and invasiveness. EphA2 is overexpressed by many human cancers, and is often associated with poor prognostic features. The clinical significance of the expression of EphA2 was observed in breast, prostate, colon, skin, cervical, ovarian, and lung cancers. EphA2 may serve as a novel target for bladder cancer, colonic adenocarcinoma and ovarian cancer therapy.
• Synonyms: Ephrin type-A receptor 2, Epithelial cell kinase, Eph receptor A2