Cytochrome P450 2A6 (CYP2A6) Mouse Monoclonal Antibody [Clone ID: F16 P2 D8]

CAT#: AM05370PU-N

Cytochrome P450 2A6 (CYP2A6) mouse monoclonal antibody, clone F16 P2 D8, Purified

Product Images

Left: Western blot using CYP2A6 antibody on recombinant cytochrome p450 at 1 ug/ml. Right: Staining using CYP2A6 antibody on normal human liver tissue at 1 ug/ml.

Specifications

Product Data

• Clone Name: F16 P2 D8
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on paraffin sections.
  Western Blot: 1 - 2 µg/ml.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with Synthetic peptide conjugated to ovalbumin derived from the C-terminus of CYP2A6 and mouse myeloma Ag8563 cells. Antigen identical in CYP2A6, 2A7 and 2A13.
• Specificity: This antibody reacts to Cytochrome p450 2A6.
• Formulation: Phosphate buffered saline with 0.08% sodium azide
  State: Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: cytochrome P450 family 2 subfamily A member 6
• Database Link:
  Entrez Gene 1548 Human
  UniProt ID P11509
• Background: The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP2A6 is a liver enzyme that metabolizes a number of drugs and a variety of procarcinogens, though it is primarily responsible for the metabolism of nicotine, the major addictive agent in tobacco. CYP2A6 inactivates nicotine to cotinine, and then cotinine to 3-hydroxycotinine. Differences in CYP2A6 genotypes are related to nicotine dependence, and may influence smoking habits and withdrawal symptoms in individuals that are quitting smoking. This suggests that an individualized smoking cessation program may be designed based on CYP2A6 genotypes.
• Synonyms: CYP2A3,Cytochrome P450 2A6, CYPIIA6, CYPIIA3