CD21 (CR2) Mouse Monoclonal Antibody [Clone ID: LT21]

CAT#: AM03064FC-N

CD21 (CR2) mouse monoclonal antibody, clone LT21, FITC

Product Images

Double staining of human, canine and porcine B lymphocytes with anti-CD79a (HM57) and anti-CD21 (LT21) antibody

Specifications

Product Data

• Clone Name: LT21
• Applications: FC
• Recommended Dilution: Flow Cytometry analysis of Human blood cells using 20 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension.
• Reactivities: Bovine, Canine, Human, Porcine
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: IM9 human B-lymphoblastoid cell line
• Specificity: The antibody LT21 reacts with CD21 (CR2), a 145 kDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells, some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature B cells.
• Formulation: PBS
  Label: FITC
  State: Liquid purified IgG fraction
  Preservative: 15 mM Sodium Azide
  Label: Conjugated with Fluorescein isothiocyanate under optimum conditions.
• Conjugation: FITC
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  This product is photosensitive and should be protected from light.
  
• Stability: Shelf life: one year from despatch.
• Gene Name: complement component 3d receptor 2
• Database Link:
  Entrez Gene 1380 Human
  UniProt ID P20023
• Background: CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.
• Synonyms: Complement receptor type 2, CR2, C3DR, C3d receptor, EBV Receptor, Dendritic Cell Marker