TREX1 (NM_016381) Human Recombinant Protein

CAT#: TP761837

Purified recombinant protein of Human three prime repair exonuclease 1 (TREX1), transcript variant 1, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding human full-length TREX1
• Tag: N-GST and C-His
• Predicted MW: 66.7 kDa
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50 mM Tris-HCl, pH 8.0, 8 M urea
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_057465
• Locus ID: 11277
• UniProt ID: Q9NSU2
• Cytogenetics: 3p21.31
• Refseq Size: 2216
• Refseq ORF: 1107
• Synonyms: AGS1; CRV; DRN3; HERNS
• Summary: This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytosolic DNA-sensing pathway