B7H4 (VTCN1) Human Recombinant Protein

CAT#: TP728037

Biotinylated Human B7-H4 (C-Fc-Avi)

Specifications

Product Data

• Species: Human
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Phe29-Ala258
• Tag: C-Fc-Avi
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS,pH7.4.
• Note: Biotinylated Recombinant Human B7 Homolog 4 is produced by our Mammalian expression system and the target gene encoding Phe29-Ala258 is expressed with a Fc, Avi tag at the C-terminus.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 79679
• UniProt ID: Q7Z7D3
• Summary: B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellular domain (ECD) with two Ig-like V-type domains, a 21 aa transmembrane segment, and a 2 aa cytoplasmic tail. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.