ICAM1 Human Recombinant Protein

CAT#: TP727952

Recombinant Human Intercellular Adhesion Molecule 1/ICAM-1/CD54 (C-Fc)

Specifications

Product Data

• Species: Human
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Asn26-Glu480
• Tag: C-Fc
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
• Note: Recombinant Human Intercellular Adhesion Molecule 1 is produced by our Mammalian expression system and the target gene encoding Asn26-Glu480 is expressed with a Fc tag at the C-terminus.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 3383
• UniProt ID: P05362
• Summary: Inter-Cellular Adhesion Molecule 1 (ICAM1) is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. As an endothelial and leukocyte-associated transmembrane protein, ICAM1 is well known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration. The presence of heavy glycosylation and other structural characteristics lend ICAM1 binding sites for a number of immune-associated ligands. Notably, ICAM-1 binds to macrophage adhesion ligand-1 (Mac-1; ITGB2 / ITGAM), leukocyte function associated antigen-1 (LFA-1/integrin), and fibrinogen.ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds.