Kitl Mouse Recombinant Protein

CAT#: TP726886

Recombinant Mouse Stem Cell Factor/SCF/c-Kit Ligand

Specifications

Product Data

• Species: Mouse
• Protein Source: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Lys26-Ala189
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
• Note: Recombinant Mouse Stem Cell Factor is produced by our E.coli expression system and the target gene encoding Lys26-Ala189 is expressed.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 17311
• UniProt ID: P20826
• Summary: Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.