Cd24a Mouse Recombinant Protein
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Specifications
Product Data | |
Species | Mouse |
Protein Source | Human |
Expression cDNA Clone or AA Sequence |
Asn27-Gly53
|
Tag | C-Fc |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. |
Note | Recombinant Mouse Signal Transducer CD24 is produced by our Mammalian expression system and the target gene encoding Asn27-Gly53 is expressed with a Fc tag at the C-terminus. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 12484 |
UniProt ID | P24807 |
Summary | Signal Transducer CD24 is a heavily and variably glycosylated GPI-linked sialoprotein. Human CD24 is expressed on B lineage cells and granulocytes, on epithelial, neuronal, and muscle cells, and on a range of tumor cells. CD24 expression is regulated during lineage development and with the activation of various cell types. Antibody crosslinking of CD24 enhances the induction of apoptosis in B and T lymphocytes which contributes to negative selection and the induction of immune tolerance. CD24 on antigen presenting cells cooperates with B7 molecules in the costimulation of T cells. CD24 associates in cis with Siglec10 and with the danger-associated molecules HMGB1, HSP70, or HSP90 which are released from necrotic or damaged cells. Formation of these ternary complexes fills a protective role: the resulting Siglec10 signaling inhibits inflammatory responses that are otherwise induced by extracellular DAMPs. |
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