IL10 Human Recombinant Protein

CAT#: TP726138

Recombinant Human Interleukin-10/IL-10 (tag free)

Specifications

Product Data

• Species: Human
• Protein Source: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Ser19-Asn178
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4
• Note: Recombinant Human Interleukin-10 is produced by E. coli. The target gene encoding Ser19-Asn178 is expressed.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 3586
• UniProt ID: P22301
• Summary: Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor (CSIF), is a secreted protein that belongs to the IL-10 family. IL-10 is secreted by various mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. As a major immune regulatory cytokine, IL-10 has profound anti-inflammatory functions on many cells of the immune system, limiting excessive tissue disruption caused by inflammation. Studies showed that IL-10 provides a feedback loop to limit the effector functions of macrophages and DCs on T cells. Once expressed, IL-10 signals through the IL-10 receptor (IL-10R) to activate STAT3. In addition to elevated levels in parasitic infection, high expression levels of IL-10 are also found in retroviral infections inducing immunodeficiency. The immunosuppressive properties of IL-10 suggest a possible clinical use of IL-10 in suppressing rejections of grafts after organ transplantations