Thyroglobulin (TG) (NM_003235) Human Recombinant Protein

CAT#: TP701224-B

Purified recombinant protein of Human thyroglobulin (TG), Asn20-End, with C-terminal His and site-specific Biotinylation on the C-terminal AVI-plus tag, expressed in HEK293 cells, 50ug

Product Images

Purified recombinant protein TG was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence from TrueORF clone, RC216216, encoding the region(Asn20-End) of TG
• Tag: C-AVI-PLUS
• Predicted MW: 306.0 kDa
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: PBS, pH 7.4, 10% glycerol
• Bioactivity: The biotin to protein ratio is 1 as determined by Streptavidin Pull-Down Assay.
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_003226
• Locus ID: 7038
• UniProt ID: P01266
• Cytogenetics: 8q24.22
• Refseq Size: 8453
• Refseq ORF: 8304
• Synonyms: AITD3; TGN
• Summary: Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
• Protein Families: Druggable Genome
• Protein Pathways: Autoimmune thyroid disease