GUCY2D (NM_000180) Human Recombinant Protein

CAT#: TP318368

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Recombinant protein of human guanylate cyclase 2D, membrane (retina-specific) (GUCY2D)


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USD 788.00


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    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human guanylate cyclase 2D, membrane (retina-specific) (GUCY2D)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 119.9 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000171
Locus ID 3000
Refseq Size 3621
Cytogenetics 17p13.1
Refseq ORF 3309
Synonyms CACD1; CORD5; CORD6; CYGD; GUC1A4; GUC2D; LCA; LCA1; RCD2; retGC; RETGC-1; ROS-GC1; ROSGC
Summary This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Olfactory transduction, Purine metabolism

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