alpha Tubulin (TUBA1A) (NM_006009) Human Recombinant Protein

CAT#: TP308669

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Recombinant protein of human tubulin, alpha 1a (TUBA1A)


 Product Datasheet for 'TP308669'

  View other "TUBA1A" proteins (3)

USD 748.00


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    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human tubulin, alpha 1a (TUBA1A)
Species Human
Expression Host HEK293T
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC208669. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-Myc/DDK
Predicted MW 50 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_006000
Locus ID 7846
Refseq Size 1930
Cytogenetics 12q13.12
Refseq ORF 1353
Synonyms B-ALPHA-1; LIS3; TUBA3
Summary Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Protein Families Druggable Genome
Protein Pathways Gap junction, Pathogenic Escherichia coli infection

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BOGO Free lysates
68 Mouse Clones
HUMAN PROREINS 101