MAPKAP Kinase 2 (MAPKAPK2) (NM_032960) Human Recombinant Protein
SKU
TP308563
Recombinant protein of human mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2), transcript variant 2, 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 45.4 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_116584 |
| Locus ID | 9261 |
| UniProt ID | P49137 |
| Cytogenetics | 1q32.1 |
| RefSeq Size | 3071 |
| RefSeq ORF | 1200 |
| Synonyms | MAPKAP-K2; MK-2; MK2 |
| Summary | This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. provided by RefSeq, Jul 2008 |
| Protein Categories | Cytokines, Enzyme: Kinases, Growth Factors, Membrane Proteins |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | MAPK signaling pathway, Neurotrophin signaling pathway, VEGF signaling pathway |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "MAPKAP Kinase 2" proteins (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH308563 | MAPKAPK2 MS Standard C13 and N15-labeled recombinant protein (NP_116584) | 10 ug |
$3,360.00
|
|
| PH320487 | MAPKAPK2 MS Standard C13 and N15-labeled recombinant protein (NP_004750) | 10 ug |
$3,360.00
|
|
| LC409844 | Lyophilized MAPKAPK2 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC417772 | Lyophilized MAPKAPK2 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY409844 | Transient overexpression lysate of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2), transcript variant 2 (as WB positive control) | 100 ug |
$436.00
|
|
| LY417772 | Transient overexpression lysate of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2), transcript variant 1 (as WB positive control) | 100 ug |
$436.00
|
|
| TP320487 | Recombinant protein of human mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2), transcript variant 1, 20 µg | 20 ug |
$737.00
|
|
Citations
MYC transcription activation mediated by OCT4 as a mechanism of resistance to 13-cisRA-mediated differentiation in neuroblastoma
Wei, Nguyen, Yang et al
Cell Death Dis (2020) 11 (5), 368 DOI: 10.1038/s41419-020-2563-4
Wei, Nguyen, Yang et al
Cell Death Dis (2020) 11 (5), 368 DOI: 10.1038/s41419-020-2563-4
Cited by 32
AI Summary: In this study, OriGene products were used for gene knockdown experiments, specifically employing OriGene’s MK2 shRNA (catalog # TL312481) and OCT4 shRNA (catalog # TL309082), to investigate the roles of MK2 and OCT4 in regulating MYC expression and resistance to 13-cisRA-mediated differentiation in neuroblastoma.
Showing 1-1 of 1 papers.
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