Interleukin-8 / IL8 (78 aa) Human Protein

CAT#: SA6054X

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Interleukin-8 / IL8 (78 aa) human recombinant protein, 0.5 mg



USD 620.00


Availability*
2 Weeks

Size
    • 500 ug


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Specifications

Product Data
Description Interleukin-8 / IL8 (78 aa) human recombinant protein, 0.5 mg
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MAVLPRSAKE LRCQCIKTYS KPFHPKFIKE LRVIESGPHC ANTEIIVKLS DGRELCLDPK ENWVQRVVEK FLKRAENS
Predicted MW 9 kDa
Concentration 1.0 mg/ml
Purity >95% by SDS-PAGE
Buffer Presentation State: Purified
State: Liquid purified protein
Buffer System: Phosphate buffer saline (pH 7.4)
Endotoxin < 1.0 EU per 1ug of protein (determined by LAL method)
Preparation Liquid purified protein
Protein Description Recombinant Human Interleukin-8 / IL-8, aa 23-99 was expressed in E.coli and purified by using conventional chromatography techniques.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000575
Locus ID 3576
Cytogenetics 4q13.3
Synonyms GCP-1; GCP1; IL8; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1
Summary The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, May 2020]
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Bladder cancer, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway

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