Alpha-Synuclein / SNCA (E46K Mutant)

CAT#: SA6009X

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Alpha-Synuclein E46K was overexpressed in E. coli and purified to apparent homogenity by using conventional column chromatography techniques.


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USD 620.00


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2 Weeks

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    • 500 ug


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Product Data
Description Alpha-Synuclein E46K was overexpressed in E. coli and purified to apparent homogenity by using conventional column chromatography techniques.
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKKGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Predicted MW 14.459 kDa
Concentration 1.0 mg/ml (by BCA assay)
Purity > 95 % by SDS-PAGE
Buffer 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl
Preparation Liquid protein
Reference Data
RefSeq NP_000336
Locus ID 6622
Cytogenetics 4q22.1
Synonyms NACP; PARK1; PARK4; PD1
Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Parkinson's disease

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