Alpha-Synuclein / SNCA (1-140)

CAT#: SA6001FD

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Purified human recombinant alpha-Synuclein (amino acids 1-140).


Product Datasheet for 'SA6001FD'


USD 250.00


Availability*
2 Weeks

Size
    • 100 ug


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Specifications

Product Data
Description Purified human recombinant alpha-Synuclein (amino acids 1-140).
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Predicted MW 14.46 kDa
Purity > 95 %
Buffer 20 mM Tris-HCl buffer (pH 7.5), 100 mM NaCl, 1mM MgCl2
Endotoxin < 1.0 EU per 1 ug of protein (determined by LAL method)
Reconstitution Restore in sterile distilled water to a concentration of 1 mg/ml or less.
Preparation Lyophilized from a 0.2 um filtered solution
Reference Data
RefSeq NP_000336
Locus ID 6622
Cytogenetics 4q22.1
Synonyms NACP; PARK1; PARK4; PD1
Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Parkinson's disease

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