Collagen type III alpha 1 chain Bovine Protein

CAT#: RA006

Collagen type III alpha 1 chain bovine protein, 0.5 mg

Specifications

Product Data

• Species: Bovine
• Protein Source: Placenta
• Concentration: lot specific
• Purity: >98% Chromatographically and immunologically pure.
• Buffer: State: Liquid (sterile filtered) purified Ig fraction.
  Buffer System: 0.5M Acetic Acid, pH 4.5 containing 0.01% Sodium Azide as preservative and without stabilizers.
• Preparation: Liquid (sterile filtered) purified Ig fraction.
• Applications: Suitable for use as a control or standard in indirect trapping ELISA for quantitation of antigen in serum using a standard curve, for Immunoprecipitation and for Western blotting.
• Protein Description: This antigen has been prepared from bovine placenta and is free from other collagens, serum proteins and non-collagen extracellular matrix proteins. Reacts with anti-Collagen Type III. Reaction with anti-Collagen I, II, IV, V or VI is negligible (typically less than 1% cross reactivity was detected by ELISA.
• Storage: Store vial at 2-8°C prior to opening.
  This product is stable 2-8°C as an undiluted liquid.
  Dilute only prior to immediate use.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_000081
• Locus ID: 1281
• Cytogenetics: 2q32.2
• Synonyms: EDS4A; EDSVASC; PMGEDSV
• Summary: This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
• Protein Families: Druggable Genome
• Protein Pathways: ECM-receptor interaction, Focal adhesion