Cardiac Troponin I Human Protein
|Description||Cardiac Troponin I human protein, 10 µg|
|Protein Source||Cardiac muscle|
|Purity||>95% by SDS-PAGE|
Buffer System: 7M Urea, 5 mM EDTA, 20 mM Tris
Preservative: 15 mM Mercaptoethanol
|Protein Description||Purified native Human Troponin I from Human heart|
|Note||Caution: Blood samples of the tissue donor for this product was tested and found negative for HBsAg, HCV, syphillis and HIV-I and HIV-II antibodies. Nevertheless, all products from human sources should be handled as potentially infectious.|
|Storage||Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Synonyms||CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1|
|Summary||Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]|
|Protein Families||Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency|
|Protein Pathways||Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)|
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