Cardiac Troponin I Human Protein

Cardiac Troponin I human protein, 10 µg



USD 485.00


Availability*
5 Days

Size
    • 10 ug


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Specifications

Product Data
Description Cardiac Troponin I human protein, 10 µg
Species Human
Protein Source Cardiac muscle
Concentration 1.0 mg/ml
Purity >95% by SDS-PAGE
Buffer State: Liquid
Buffer System: 7M Urea, 5 mM EDTA, 20 mM Tris
Preservative: 15 mM Mercaptoethanol
Preparation Liquid
Applications ELISA.
Protein Description Purified native Human Troponin I from Human heart
Note Caution: Blood samples of the tissue donor for this product was tested and found negative for HBsAg, HCV, syphillis and HIV-I and HIV-II antibodies. Nevertheless, all products from human sources should be handled as potentially infectious.
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000354
Locus ID 7137
Cytogenetics 19q13.42
Synonyms CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1
Summary Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency
Protein Pathways Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

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