KLF4 (11-395, His-tag)

USD 820.00


Availability*
2 Weeks

Size
    • 500 ug


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Specifications

Product Data
Species Human
Expression Host E. coli
Tag His-tag
Predicted MW 44.2 kDa
Concentration 1.0 mg/ml (determined by Bradford assay)
Purity > 85 % by SDS - PAGE
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
Preparation Liquid purified protein
Reference Data
RefSeq NP_001300981
Locus ID 9314
Cytogenetics 9q31.2
Synonyms EZF; GKLF
Summary This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Protein Families Adult stem cells, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors

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68 Mouse Clones